Health
Study Suggests Maintaining Klotho Protein Levels Protects Against ALS-Related Nerve Degeneration

Amyotrophic lateral sclerosis, also known as ALS or Lou Gherig’s Disease after the famous baseball player who was forced to retire after experiencing the disease, is a fatal neurodegenerative disease. The medical term for ALS accurately describes the effects the disease has on patients. Amyotrophic refers to three root terms: a meaning “no,” myo meaning “muscle,” and trophic meaning nourishment, all of which combine to indicate that the condition leads to no nourishment of muscle tissue and atrophy, or wasting away, of the affected tissue. Lateral indicates the upper and lower areas of the spinal cord that lead to muscle atrophy, and sclerosis refers to the hardening and scarring of the affected regions.
In ALS, motor neurons that provide an essential connection between the brain and spinal cord and the rest of the body degenerate or deteriorate rapidly. When the motor neurons eventually die, the brain can no longer cause or control muscle movement, leading to their eventual atrophy. Soon after, individuals can experience partial or total paralysis of voluntary muscles, leading to an inability to control muscle movement, speak, eat, and even breathe. The average life expectancy after receiving an ALS diagnosis is between three and five years.
Lack of Available Treatments
Currently, there is no cure for ALS. While familial, or inherited, ALS accounts for some cases of the disease, nearly 95% of cases occur sporadically, without any known genetic precursor.
In an effort to find a potential preventive treatment for ALS and other neurodegenerative diseases, researchers at Boston University’s School of Medicine have turned to study biological models that simulate neurodegenerative conditions. As a result, scientists have identified a certain protein that appears to serve a unique, beneficial purpose in protecting the brain from the mechanisms of ALS.
Klotho Protein
In Boston University’s School of Medicine laboratory model, researchers identified an anti-aging protein called klotho protein that showed neuroprotective effects. In fact, increasing klotho protein levels reduced neurological deficits in experimental models of both Alzheimer’s Disease and multiple sclerosis (MS). Researchers then posited that klotho protein increases may aid in protecting the brain against other neurodegenerative diseases, as well.
In a subsequent study on a laboratory model, klotho protein provided similar neuroprotective effects against ALS. Klotho protein was shown to reduce ALS-associated neurological deficits, thus providing a potential decrease in the manifestation of symptoms. In conjunction with the presence of anti-inflammatory brain cells called microglia, klotho protein shows potential to protect the brain against inflammation, degeneration, and motor neuron loss.
Future Implications
Klotho protein therapy, along with other activities that increase klotho levels, have been shown to potentially prolong the life of an ALS patient by as much as 300 days. Further, increasing klotho levels appears to improve quality of life by reducing ALS symptoms in patients who have already discovered the disease.
While the klotho protein has long shown benefits for other neurodegenerative diseases, this new information provides hope and potential therapeutic applications for the thousands of patients currently suffering from ALS.
Resources:
https://www.eurekalert.org/pub_releases/2019-06/buso-pop062719.php
https://link.springer.com/article/10.1007/s12031-019-01356-2
https://www.als.org/understanding-als/what-is-als
Health
Dr. Teresa Tyson, DNP, Discusses The Hidden Healthcare Crisis in Remote Regions

Image source: Dr. Teresa Tyson, DNP, and Health Wagon
Access to healthcare remains a challenge for many individuals living in rural and remote areas, where medical facilities are scarce or difficult to reach. Many residents endure long travel times for even basic medical services, leading to delayed diagnoses and worsening health conditions. The lack of healthcare professionals further compounds the issue, leaving communities with inconsistent or inadequate care.
While technology and government initiatives have made strides in addressing these disparities, Dr. Teresa Tyson, DNP, notes how there are many obstacles still hindering widespread improvement. Bridging the healthcare gap requires a combination of innovative solutions, infrastructure development, and policy changes to ensure that medical services reach those who need them most.
Limited Access to Medical Care
Many remote regions struggle with a severe lack of healthcare facilities, leaving residents with minimal options for medical treatment. Hospitals and clinics are often located hours away, making even routine checkups a logistical challenge.
A shortage of medical professionals further worsens the situation, as many doctors and nurses prefer to work in urban areas with better resources and career opportunities. As a result, rural communities often rely on understaffed clinics or visiting healthcare workers who may not be available consistently. This leads to delayed diagnoses and inadequate treatment for chronic conditions. Many rural clinics operate with limited medical supplies, making it difficult to provide comprehensive care even when healthcare professionals are available.
In some cases, patients must travel long distances just to receive basic care, often at great personal and financial costs. The burden of transportation, time off work, and the uncertainty of available treatment discourage many from seeking medical attention until their conditions become severe.
Health Risks and Consequences
Delays in medical care often mean that conditions that could have been treated early turn into serious health complications. Many individuals in remote areas develop chronic illnesses that go undiagnosed for years simply because healthcare services are too far away or difficult to access. Diseases that are manageable with regular monitoring, such as diabetes or hypertension, frequently spiral out of control due to the lack of consistent medical supervision.
Beyond physical health, the absence of adequate healthcare also takes a toll on mental well-being. Isolation and limited access to mental health professionals leave many struggling with anxiety, depression, and other psychological conditions without proper support. In small, tight-knit communities, stigma around mental health can make it even harder for individuals to seek help, further exacerbating the crisis.
Preventable diseases continue to spread in these areas due to the lack of vaccinations, screenings, and early interventions. Without proper healthcare infrastructure, outbreaks of common illnesses can have devastating effects, particularly on children and the elderly. The combination of poor access, financial barriers, and limited awareness creates a cycle where minor health concerns escalate into life-threatening conditions.
Challenges in Expanding Healthcare Services
Building and maintaining healthcare infrastructure in remote regions comes with considerable hurdles. Poor road conditions and unreliable transportation make it difficult for medical professionals to reach patients, and in some cases, ambulances are unavailable, forcing residents to rely on personal vehicles or community efforts to transport those in need. In areas with extreme weather conditions, seasonal challenges further complicate healthcare delivery, cutting off entire communities during certain times of the year. These conditions make it nearly impossible for emergency medical teams to provide timely assistance in critical situations.
Funding remains a major obstacle, as rural healthcare facilities often struggle with limited financial resources. Many small clinics operate on tight budgets, lacking essential medical equipment and supplies. Without sufficient investments, these facilities cannot expand their services, making it harder to attract and retain qualified healthcare workers. As a result, many professionals opt to work in urban settings where they have access to better salaries, career advancement, and modern medical technology.
Role of Technology in Bridging the Gap
Advancements in technology are offering new ways to connect patients in remote areas with medical professionals. Telemedicine has made it possible for individuals to consult doctors without having to travel long distances, reducing delays in diagnoses and treatment. Virtual consultations, remote monitoring, and mobile health apps allow patients to receive medical advice without needing to visit overcrowded or distant healthcare facilities. In addition to telemedicine, artificial intelligence is being used to assist in diagnosing conditions remotely, helping bridge the gap in specialist care.
Despite its potential, implementing technology-driven healthcare solutions in rural regions is not without obstacles. Many areas lack reliable internet access or the necessary digital literacy to make full use of telehealth services. Even when technology is available, the cost of devices and connectivity can create another barrier, preventing low-income households from benefiting fully. Addressing these issues requires a combination of infrastructure development, education, and financial support to ensure that technology can be effectively integrated into rural healthcare systems.
Efforts to Improve Rural Healthcare
Governments and nonprofit organizations are actively working to address the healthcare challenges faced by remote communities. Investment in medical outreach programs, mobile clinics, and training initiatives for local healthcare workers has helped bring essential services to those who need them most. Some regions have introduced incentive programs to encourage doctors and nurses to work in underserved areas, offering student loan forgiveness, housing assistance, or higher salaries.
Community-led initiatives also play a crucial role in improving healthcare access. Local volunteers and advocacy groups often step in to provide educational workshops, vaccination drives, and wellness programs tailored to the specific needs of their communities. These grassroots efforts help bridge gaps where formal healthcare systems fall short, ensuring that residents receive at least some level of medical support.
Future Prospects for Remote Healthcare
Innovations in medical technology, policy changes, and raising awareness are shaping the future of rural healthcare. The expansion of telehealth services, combined with improved infrastructure, has the potential to make healthcare more accessible and efficient. Continued investment in mobile medical units and community-based programs could ensure that even the most isolated areas receive the care they need. Research into low-cost, portable medical devices is also opening new doors for remote diagnostics and treatment.
Sustained progress will depend on collaboration between governments, healthcare providers, and local communities. Long-term solutions require more than temporary programs; they demand systemic changes that prioritize equitable medical access. If these efforts continue to grow, rural healthcare systems may finally move toward lasting improvements that benefit future generations.
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