Health

Study Suggests Maintaining Klotho Protein Levels Protects Against ALS-Related Nerve Degeneration

Published

4 years ago

March 26, 2021

Amyotrophic lateral sclerosis, also known as ALS or Lou Gherig’s Disease after the famous baseball player who was forced to retire after experiencing the disease, is a fatal neurodegenerative disease. The medical term for ALS accurately describes the effects the disease has on patients. Amyotrophic refers to three root terms: a meaning “no,” myo meaning “muscle,” and trophic meaning nourishment, all of which combine to indicate that the condition leads to no nourishment of muscle tissue and atrophy, or wasting away, of the affected tissue. Lateral indicates the upper and lower areas of the spinal cord that lead to muscle atrophy, and sclerosis refers to the hardening and scarring of the affected regions.

In ALS, motor neurons that provide an essential connection between the brain and spinal cord and the rest of the body degenerate or deteriorate rapidly. When the motor neurons eventually die, the brain can no longer cause or control muscle movement, leading to their eventual atrophy. Soon after, individuals can experience partial or total paralysis of voluntary muscles, leading to an inability to control muscle movement, speak, eat, and even breathe. The average life expectancy after receiving an ALS diagnosis is between three and five years.

Lack of Available Treatments

Currently, there is no cure for ALS. While familial, or inherited, ALS accounts for some cases of the disease, nearly 95% of cases occur sporadically, without any known genetic precursor.

In an effort to find a potential preventive treatment for ALS and other neurodegenerative diseases, researchers at Boston University’s School of Medicine have turned to study biological models that simulate neurodegenerative conditions. As a result, scientists have identified a certain protein that appears to serve a unique, beneficial purpose in protecting the brain from the mechanisms of ALS.

Klotho Protein

In Boston University’s School of Medicine laboratory model, researchers identified an anti-aging protein called klotho protein that showed neuroprotective effects. In fact, increasing klotho protein levels reduced neurological deficits in experimental models of both Alzheimer’s Disease and multiple sclerosis (MS). Researchers then posited that klotho protein increases may aid in protecting the brain against other neurodegenerative diseases, as well.

In a subsequent study on a laboratory model, klotho protein provided similar neuroprotective effects against ALS. Klotho protein was shown to reduce ALS-associated neurological deficits, thus providing a potential decrease in the manifestation of symptoms. In conjunction with the presence of anti-inflammatory brain cells called microglia, klotho protein shows potential to protect the brain against inflammation, degeneration, and motor neuron loss.

Future Implications

Klotho protein therapy, along with other activities that increase klotho levels, have been shown to potentially prolong the life of an ALS patient by as much as 300 days. Further, increasing klotho levels appears to improve quality of life by reducing ALS symptoms in patients who have already discovered the disease.

While the klotho protein has long shown benefits for other neurodegenerative diseases, this new information provides hope and potential therapeutic applications for the thousands of patients currently suffering from ALS.

Resources:

https://www.eurekalert.org/pub_releases/2019-06/buso-pop062719.php
https://link.springer.com/article/10.1007/s12031-019-01356-2
https://www.als.org/understanding-als/what-is-als

Health

What Sets Why Not Natural Supplements Above Other Supplements Companies in the U.S.

Published

2 days ago

November 21, 2024

Michelle Langton

Photo courtesy of Why Not Natural

By: Georgette Virgo

In an industry plagued by minimal regulation and questionable practices, Why Not Natural Supplements sets a new standard in transparency and scientific excellence. Founded by chemical engineer Kelin Marquet, this female-owned supplement company challenges the status quo with clean and effective formulations backed by rigorous research.

Why Not Natural Supplements’ outlook on supplement creation contrasts starkly with many competitors in the $50 billion U.S. dietary supplement market. The Food and Drug Administration (FDA) does not require pre-market approval for supplements, which leaves consumers vulnerable to potentially ineffective or harmful products. Why Not Natural Supplements has implemented stringent self-imposed standards that go far beyond regulatory requirements.

“We’re on a mission to educate consumers about what a supplement should look like,” says Kelin Marquet. “As a mother of three, I’m motivated by creating supplements that I feel comfortable giving to my own family.”

A Science-First Approach to Supplement Formulation

Why Not Natural Supplements’ commitment to scientific integrity begins with its founder. Marquet’s background in chemical engineering informs every aspect of the company’s product development process.

“I use my background and strong understanding of science to pore through research articles and choose active ingredients that work – not cheap substitutes you usually find in supplements,” Kelin Marquet explains.

This science-first perspective extends to the company’s use of bioavailable forms of nutrients and its emphasis on third-party testing. Why Not Natural Supplements rigorously tests every product—including their best-selling Organic Vitamin D3 Liquid Drops with K2, 4-in-1 Magnesium Complex, Liquid Vitamin A (10,000 IU) with Coconut MCT Oil, and many others—for purity and potency. This practice sets the company apart in an industry where such thorough quality control is far from standard.

Transparency and Clean Formulations

Why Not Natural Supplements’ transparency is evident in its viewpoint on ingredient selection and labeling. The company maintains a list of ingredients that will never appear in its products, including artificial preservatives, colors, flavors, and common allergens.

“It’s not just about what’s in a supplement – it’s essential what’s not in it, too,” Marquet emphasizes. This philosophy extends to the company’s use of clean, minimalist formulations that avoid unnecessary fillers and additives.

The company provides consumers with clear, accurate information about each product’s contents. This level of transparency is rare in an industry where, according to the National Institutes of Health, supplement labels may not always accurately reflect the product’s contents.

Kelin Marquet emphasizes that each product formulation undergoes rigorous scientific scrutiny, with every ingredient serving a specific, research-backed purpose. “We don’t just throw ingredients together because they’re trendy,” Marquet explains. “Every component in our formulas is there for a reason, in its most bioavailable form, and at the optimal dosage.”

Education and Consumer Empowerment

Why Not Natural Supplements’ mission extends beyond creating high-quality supplements to educating consumers about supplement quality and safety. The company uses its social media platforms and website to provide in-depth information about ingredient sourcing, manufacturing processes, and the science behind its formulations.

This educational outlook is particularly crucial in light of the rapid growth of e-commerce in the supplement industry. As online sales platforms capture an increasing market share, the traditional role of natural and specialty retailers as information gatekeepers is diminishing. Why Not Natural Supplements is stepping into this gap, providing consumers with the knowledge they need to understand dietary supplements and find one that best fits their needs.

“We’re not just selling supplements,” Marquet states. “We’re empowering consumers to make informed decisions about their health by showing them exactly what goes into each formula and why.”

In an industry where regulation is minimal and quality can be inconsistent, Why Not Natural Supplements stands out as a company committed to raising the bar through its science-based method, commitment to transparency, and focus on consumer education.

“Our goal is to change how individuals see natural supplements,” Marquet concludes. “We believe that by prioritizing quality, efficacy, and transparency, we can help consumers reclaim their health and trust in their supplements.”