Health

Facing Methodological Challenges, ASD Researchers Emphasize Biological Insights

Published

3 years ago

July 4, 2021

Autism is one of the most common developmental disabilities, yet widely misunderstood, both by medical professionals and the community at large. This is part of the reason many individuals with the condition do not receive a correct diagnosis until later in life, and too often fail to get appropriate support.

Such extreme variables make researching the condition difficult, as well. For example, from an insurance perspective, autism support is often limited to early behavioral interventions for children, occupational, speech, and physical therapy. In some cases, carriers allow coverage for talk therapy-style care for adults.

Unfortunately, in terms of research into these targeted interventions, methodological issues have left scientists with few answers and a lot of conflicting information.

Quality, Bias, and Other Concerns

In a meta-analysis of various early intervention studies, researchers uncovered numerous cases of bias, poor methodology, and other obstacles. These included studies that based their results on parental reports, those that exhibited a high risk of bias because the intervention provider was gauging treatment effectiveness, and still more.

Early intervention certainly seems to yield some benefit, but there are many different kinds of support available, practitioner skill varies, and other factors pose challenges to study, not to mention expensive, unreliable tools for families.

Emphasizing Basic Research

Instead of focusing on more variable and often subjective matters like early intervention therapies, researchers are instead turning their attention to basic research, an approach that looks at foundational biological mechanisms to understand bodily processes. This is critical, given that research supported by the Brain Research Foundation established a new baseline case prevalence of 2.64% of the population.

That’s more than the incidence of epilepsy, inflammatory bowel disease, and ovarian cancer, among many other conditions. Nearly everyone knows someone who’s autistic.

As part of the focus on basic research, scientists have been examining the impact certain genes associated with autism spectrum disorders may have on brain development. One, known as Cullin 3, is regarded as a high-risk gene that can lead to a number of neurological deficits, including poor coordination, as well as certain social and cognitive impairments associated with autism.

This seems to be linked to changes in brain cell migration during development. In turn, that compels certain cells, which should be part of higher-level functions, to remain stuck in other regions of the brain.

Gender Bias, Gender Differences

For many years, autistic women have been pointing to diagnostic bias as a key reason why many girls and women have been overlooked. The diagnostic standards, patients and other advocates have argued, are modeled on a particular subset of boys, which likely led to serious gaps in understanding and support.

Although there is strong evidence for this, it may not be the only issue in play, though. Other research suggests that autism actually develops differently in boys and girls – in a more strictly biological sense.

One of the most marked distinctions the new research has turned up is that, during social interactions, the differences in brain activity between autistic and non-autistic girls is not the same as the differences seen in autistic and non-autistic boys. Girls also showed a greater number of gene variants that may affect the development of the brain known as the striatum, also not seen in boys.

In some senses, these are almost distinct conditions, which makes this one of the interesting challenges with regard to study of multi-genic conditions.

We are still years away from a clear understanding of the biological mechanisms that underlie autism, but the better the condition’s processes are understood, the more targeted interventions and supports can be. Like so much other scientific research, this could be the start of a long journey with much more to discover.

Health

What Sets Why Not Natural Supplements Above Other Supplements Companies in the U.S.

Published

2 days ago

November 21, 2024

Michelle Langton

Photo courtesy of Why Not Natural

By: Georgette Virgo

In an industry plagued by minimal regulation and questionable practices, Why Not Natural Supplements sets a new standard in transparency and scientific excellence. Founded by chemical engineer Kelin Marquet, this female-owned supplement company challenges the status quo with clean and effective formulations backed by rigorous research.

Why Not Natural Supplements’ outlook on supplement creation contrasts starkly with many competitors in the $50 billion U.S. dietary supplement market. The Food and Drug Administration (FDA) does not require pre-market approval for supplements, which leaves consumers vulnerable to potentially ineffective or harmful products. Why Not Natural Supplements has implemented stringent self-imposed standards that go far beyond regulatory requirements.

“We’re on a mission to educate consumers about what a supplement should look like,” says Kelin Marquet. “As a mother of three, I’m motivated by creating supplements that I feel comfortable giving to my own family.”

A Science-First Approach to Supplement Formulation

Why Not Natural Supplements’ commitment to scientific integrity begins with its founder. Marquet’s background in chemical engineering informs every aspect of the company’s product development process.

“I use my background and strong understanding of science to pore through research articles and choose active ingredients that work – not cheap substitutes you usually find in supplements,” Kelin Marquet explains.

This science-first perspective extends to the company’s use of bioavailable forms of nutrients and its emphasis on third-party testing. Why Not Natural Supplements rigorously tests every product—including their best-selling Organic Vitamin D3 Liquid Drops with K2, 4-in-1 Magnesium Complex, Liquid Vitamin A (10,000 IU) with Coconut MCT Oil, and many others—for purity and potency. This practice sets the company apart in an industry where such thorough quality control is far from standard.

Transparency and Clean Formulations

Why Not Natural Supplements’ transparency is evident in its viewpoint on ingredient selection and labeling. The company maintains a list of ingredients that will never appear in its products, including artificial preservatives, colors, flavors, and common allergens.

“It’s not just about what’s in a supplement – it’s essential what’s not in it, too,” Marquet emphasizes. This philosophy extends to the company’s use of clean, minimalist formulations that avoid unnecessary fillers and additives.

The company provides consumers with clear, accurate information about each product’s contents. This level of transparency is rare in an industry where, according to the National Institutes of Health, supplement labels may not always accurately reflect the product’s contents.

Kelin Marquet emphasizes that each product formulation undergoes rigorous scientific scrutiny, with every ingredient serving a specific, research-backed purpose. “We don’t just throw ingredients together because they’re trendy,” Marquet explains. “Every component in our formulas is there for a reason, in its most bioavailable form, and at the optimal dosage.”

Education and Consumer Empowerment

Why Not Natural Supplements’ mission extends beyond creating high-quality supplements to educating consumers about supplement quality and safety. The company uses its social media platforms and website to provide in-depth information about ingredient sourcing, manufacturing processes, and the science behind its formulations.

This educational outlook is particularly crucial in light of the rapid growth of e-commerce in the supplement industry. As online sales platforms capture an increasing market share, the traditional role of natural and specialty retailers as information gatekeepers is diminishing. Why Not Natural Supplements is stepping into this gap, providing consumers with the knowledge they need to understand dietary supplements and find one that best fits their needs.

“We’re not just selling supplements,” Marquet states. “We’re empowering consumers to make informed decisions about their health by showing them exactly what goes into each formula and why.”

In an industry where regulation is minimal and quality can be inconsistent, Why Not Natural Supplements stands out as a company committed to raising the bar through its science-based method, commitment to transparency, and focus on consumer education.

“Our goal is to change how individuals see natural supplements,” Marquet concludes. “We believe that by prioritizing quality, efficacy, and transparency, we can help consumers reclaim their health and trust in their supplements.”